Spatially Multiplexed Imaging: Simultaneous Measurement of Multiple Biological Signals with Signaling Reporter Islands
The invention, in some aspects, relates to the preparation and use of signaling reporter islands (SiRIs) in single cells. Compositions of the invention that produce SiRIs can be delivered to a cell resulting in the presence of one or more SiRIs in the cell. Methods of the invention include detecting signals generated by elements in the SiRIs in a cell and use of the detected signals to determine and analyze simultaneous physiological processes within the cell, or cells.
Researchers
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methods for simultaneous measurement of multiple biological signals from spectrally identical fluorescent reporters
United States of America | Granted | 11,782,064
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