The Site-Specific Incorporation of a Redox-Active and Chemically-Reactive Amino Acid into Proteins in E. Coli
Invention type: Technology
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Case number: #12973J
This invention provides reductase proteins that comprise NH2Y unnatural amino acid residues, systems of orthogonal elements for incorporating NH2Y into reductases and methods of using NH2Y amino acid residues in reductases as molecular probes for probing reductases function, structure and activity.
Researchers
Peter Schultz
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Jianming Xie
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Mohammad Seyedsayamdost
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Clement Tsz Chan
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Lital Alfonta
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JoAnne Stubbe
Departments: Department of Chemistry
Technology Areas: Therapeutics: Nucleic Acids, Proteins & Antibodies
Impact Areas: Healthy Living
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genetic incorporation of 3-aminotyrosine into reductases
United States of America | Granted | 8,673,591
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