Peptide Nucleic Acid Functionalized Hydrogel Microneedles for Sampling and Detection of Interstitial Fluid Nucleic Acids

The present disclosure relates to a device, comprising a base and a plurality of microneedles attached to the base, wherein each microneedle has an outer surface; the outer surface of at least one microneedle being coated with a composition comprising at least one polymer and least one Peptide Nucleic Acid (PNA). The present disclosure additionally relates to a method of detecting an analyte in interstitial fluid (ISF), comprising contacting the device to a subject, for example, to human skin.

Researchers

Yin Hao Chang / Sylvain Ladame / Dana Al Sulaiman / Darrell J Irvine

Departments: David H Koch Institute for Integrative Cancer Res
Technology Areas: Biotechnology: Biomedical Devices & Systems, Sensors & Monitoring / Drug Discovery and Research Tools: Genomics & Proteomics / Therapeutics: Nucleic Acids
Impact Areas: Healthy Living

  • peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids
    United States of America | Published application
  • peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids
    European Patent Convention | Published application
  • peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids
    United States of America | Published application

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