Molecular Spatial Mapping Of Metastatic Tumor Microenvironment
The present invention discloses novel methods and uses thereof for producing molecular spatial maps of metastatic breast cancer (MBC) and ductal carcinoma in situ of the breast (DCIS). A specific list of genes are identified using single-cell RNA sequencing and single-nucleus RNA sequencing and are used for RNA visualization of MBC and DCIS tissue microenvironment. Unexpected subtypes of tumor cells are revealed, and methods for identifying molecular biomarkers for MBC in the bone and breast and DCIS are disclosed. Furthermore, methods for identifying therapeutic agents and uses thereof for treating MBC and DCIS as well as compositions thereof comprising such identified therapeutic agents are provided.
Researchers
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molecular spatial mapping of metastatic tumor microenvironment
United States of America | Published application | 0
Publications
Klughammer, J., D. L. Abravanel, Å. Segerstolpe, T. R. Blosser, Y. Goltsev, Y. Cui, D. R. Goodwin, et al. "A Multi-Modal Single-Cell and Spatial Expression Map of Metastatic Breast Cancer Biopsies Across Clinicopathological Features." Nature Medicine 30, no. 11 (November 2024): 3236–3249. https://doi.org/10.1038/s41591-024-03215-z.
Abravanel, Daniel L., et al. "Abstract PD6-03: Spatio-molecular dissection of the breast cancer metastatic microenvironment." Cancer Research 82, no. 4_Supplement (February 15, 2022): PD6–03. https://doi.org/10.1158/1538-7445.SABCS21-PD6-03.
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