Micromolded Particles for Cancer Treatment

Exclusively Licensed

Microparticulate compositions and methods for delivery and pulsatile release of one or more sting agonists and/or receptors have been developed. The compositions include polymeric microdevices formed from biodegradable and biocompatible polymers or co-polymers thereof including a shell and compartment(s) or discrete regions in the compartment(s) formed by an additive process such as micromolding, three-dimensional printing and lithography. The compositions include microdevices that release individual doses of incorporated STING agonist and/or receptors at defined times, for example, in pulses up to several months after administration with essentially no leakage between releases.

Researchers

Robert Langer / Xueguang Lu / Ana Jaklenec

Departments: Office of the Institute Professors, David H Koch Institute for Integrative Cancer Res
Technology Areas: Biotechnology: Biomanufacturing, Synthetic Biology / Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Proteins & Antibodies, Small Molecules
Impact Areas: Healthy Living

  • compositions of polymeric microdevices and methods of use thereof in cancer immunotherapy
    United States of America | Published application
  • compositions of polymeric microdevices and methods of use thereof in cancer immunotherapy
    Australia | Granted | 2,021,270,750
  • compositions of polymeric microdevices and methods of use thereof in cancer immunotherapy
    Canada | Published application
  • compositions of polymeric microdevices and methods of use thereof in cancer immunotherapy
    China | Published application
  • compositions of polymeric microdevices and methods of use thereof in cancer immunotherapy
    European Patent Convention | Published application
  • compositions of polymeric microdevices and methods of use thereof in cancer immunotherapy
    Israel | Pending
  • compositions of polymeric microdevices and methods of use thereof in cancer immunotherapy
    Japan | Published application
  • compositions of polymeric microdevices and methods of use thereof in cancer immunotherapy
    Mexico | Pending
  • compositions of polymeric microdevices and methods of use thereof in cancer immunotherapy
    New Zealand | Pending
  • compositions of polymeric microdevices and methods of use thereof in cancer immunotherapy
    South Africa | Pending

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