Method and Apparatus for Inferring Elevated Pulmonary Capillary Wedge Pressures from Single-Lead Electrocardiogram Telemetry Data

A system and method are provided for monitoring patients with heart failure. The method includes receiving physiological data associated with a patient. The method also includes determining a data portion satisfying a signal-quality-index condition. The method also includes determining a probability value for the data portion with a model developed, for example, via machine learning using training data. The method also includes determining whether an exacerbation condition is satisfied based on the probability value, and, in response to determining that the exacerbation condition is satisfied, generating and transmitting an exacerbation alert associated with the patient.