Kirigami-Inspired Stents for Sustained Local Delivery of Therapeutics

This invention introduces a kirigami-inspired injectable stent system designed for radial, circumferential, and longitudinal delivery of therapeutics within tubular structures like the gastrointestinal (GI) tract and trachea. The technology addresses challenges associated with coated stents, such as complications like migration and tissue perforation in the GI tract, by enabling rapid circumferential submucosal deposition of controlled drug-releasing systems. Specifically developed for extended multi-centimeter segments affected by various GI pathologies, this kirigami-mediated stent system facilitates ultra-long local drug release through the deposition of drug-loaded polymeric particles in the tubular mucosa, offering a solution for treating conditions like inflammatory bowel disease and eosinophilic GI disorders.