Ionizable Lipid OF-02 and its Use in mRNA Delivery
Invention type: Technology
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Case number: #17733
Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
Researchers
Joseph Dorkin
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Owen Fenton
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Kevin Kauffman
/
Rebecca McClellan
/
Daniel Anderson
Departments: Department of Chemical Engineering
Technology Areas: Chemicals & Materials: Catalysis & Synthesis / Drug Delivery: Microparticles & Nanoparticles
Impact Areas: Healthy Living, Advanced Materials
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alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
United States of America | Granted | 10,201,618 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
European Patent Convention | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Canada | Published application -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
China | Granted | 107,848,988 -
alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell
Australia | Granted | 2,016,278,970 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Hong Kong | Granted | 1,251,901 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
United States of America | Granted | 10,695,444 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
United States of America | Granted | 11,679,165 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Australia | Granted | 2,021,200,199 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Australia | Pending -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Austria | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Bulgaria | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Belgium | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Switzerland | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Liechtenstein | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Czech Republic | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Germany | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Denmark | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Estonia | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Spain | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Finland | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
France | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
United Kingdom | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Greece | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Croatia | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Hungary | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Ireland | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Italy | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Lithuania | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Luxembourg | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Netherlands | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Norway | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Poland | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Portugal | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Romania | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Serbia | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Sweden | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Slovenia | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Slovakia | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Turkey | Granted | 3,310,764 -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
European Patent Convention | Published application -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
United States of America | Published application -
alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
Hong Kong | Published application
Publications
Fenton, O. S., et al. "Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery." Advanced Materials 28, no. 15 (April 20, 2016): 2939–43. https://doi.org/10.1002/adma.201505822.
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