Intracell Delivery by Mechanical Membrane Poration
Exclusively Licensed
Invention type: Technology
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Case number: #14730
A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
Researchers
Robert Langer
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Janeta Zoldan
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Woo Young Sim
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Armon Sharei
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Andrea Adamo
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Daniel Anderson
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Klavs F. Jensen
Departments: Office of the Institute Professors, Department of Chemical Engineering
Technology Areas: Drug Delivery: Microparticles & Nanoparticles
Impact Areas: Healthy Living
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devices and systems for delivery of materials to cells
United States of America | Published application -
intracellular delivery
Korea (south) | Granted | 10 -
intracellular delivery
European Patent Convention | Published application -
intracellular delivery
Japan | Granted | 6,629,272 -
intracellular delivery
United States of America | Granted | 10,696,944 -
intercellular delivery
Brazil | Granted | 0 -
intracellular delivery
Canada | Granted | 2,852,672 -
intercellular delivery
China | Granted | 0 -
intercellular delivery
India | Granted | 346,694 -
intercellular delivery
Japan | Granted | 6,219,832 -
intercellular delivery
Russian Federation | Granted | 2,656,156 -
intercellular delivery
Australia | Granted | 2,012,326,203 -
intercellular delivery
Austria | Granted | 2,768,942 -
intercellular delivery
Belgium | Granted | 2,768,942 -
intercellular delivery
Switzerland | Granted | 2,768,942 -
intercellular delivery
Liechtenstein | Granted | 2,768,942 -
intercellular delivery
Germany | Granted | 2,768,942 -
intercellular delivery
Denmark | Granted | 2,768,942 -
intercellular delivery
Spain | Granted | 2,768,942 -
intercellular delivery
France | Granted | 2,768,942 -
intercellular delivery
United Kingdom | Granted | 2,768,942 -
intercellular delivery
Ireland | Granted | 2,768,942 -
intercellular delivery
Italy | Granted | 2,768,942 -
intercellular delivery
Luxembourg | Granted | 2,768,942 -
intercellular delivery
Netherlands | Granted | 2,768,942 -
intercellular delivery
Sweden | Granted | 2,768,942 -
intracell delivery by mechanical membrane poration
China | Granted | 0 -
intracell delivery
Hong Kong | Granted | 40,059,870 -
intracellular delivery
Hong Kong | Published application -
intracell delivery by mechanical membrane poration
India | Granted | 481,863 -
intracell delivery
China | Granted | 113,337,402
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