Device and Method for Isolation and Detection of Target Cells/Particles from Complex Background Matrices

Embodiments disclosed herein relate to methods and devices for detecting targets in a sample. A plurality of targets in a sample and a plurality of particles may be provided in a volume and configured to bind to one another to form bound particle-target complexes. In some embodiments, the volume may also include one or more density gradient or two or more density media which may form an interface. The bound particle-target complexes may experience a density shift and separation in the density media relative to unbound targets and/or unbound particles. In some such embodiments, the bound particle-target complexes may settle at the interface formed by the density media. In some embodiments, the separated bound particle-target complexes may then undergo concentration, extraction, and analysis steps.

Researchers

Rohit Karnik / Emily Hanhauser / Michael Bono / Mary Strawser

Departments: Department of Mechanical Engineering
Technology Areas: Diagnostics: Assays
Impact Areas: Healthy Living

  • device and method for isolation and detection of targets in a sample
    Patent Cooperation Treaty | Published application
  • device and method for isolation and detection of targets in a sample
    United States of America | Pending

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