Composition and Methods to Generate Assymetric Bispecific Antibodies from a Single Cell Line
Invention type: Technology
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Case number: #17698
Described herein are mutations in the CH1/CL interface and CH3 constant regions of a bispecific antibody which facilitate heterodimerization and methods for the efficient production of bispecific antibodies. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
Researchers
Ram Sasisekharan
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Andrew Hatas
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Eduardo Fleischer
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Vidya Subramanian
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Kannan Tharakaraman
Departments: School of Engineering, Department of Chemical Engineering
Technology Areas: Biotechnology: Synthetic Biology / Diagnostics: Assays / Drug Discovery and Research Tools: Antibodies / Therapeutics: Proteins & Antibodies
Impact Areas: Healthy Living
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bispecific antibodies having constant region mutations and uses therefor
United States of America | Granted | 11,459,405 -
bispecific antibodies having constant region mutations
and uses therefor
Japan | Published application
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