Circulating Tumor Cell Isolation by Size Selective Tagging in a Microfluidic Device

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Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.

Researchers

Robert Langer / Nahyun Cho / Viktor Adalsteinsson / Armon Sharei / J. Christopher Love / Klavs F. Jensen

Departments: Office of the Institute Professors, Department of Chemical Engineering
Technology Areas: Biotechnology: Biomedical Devices & Systems, Cell Separation, Synthetic Biology / Diagnostics: Assays / Drug Discovery and Research Tools: Cell Interrogation / Sensing & Imaging: Chemical & Radiation Sensing, Optical Sensing
Impact Areas: Healthy Living

  • selective delivery of material to cells
    Italy | Granted | 3,033,184
  • selective delivery of material to cells
    Australia | Granted | 2,014,306,423
  • selective delivery of material to cells
    Canada | Granted | 2,921,579
  • selective delivery of material to cells
    China | Granted | 105,848,793
  • selective delivery of material to cells
    European Patent Convention | Granted | 3,033,184
  • selective delivery of material to cells
    Israel | Granted | 244,113
  • selective delivery of material to cells
    Japan | Granted | 6,502,940
  • selective delivery of material to cells
    Mexico | Granted | 382,654
  • selective delivery of material to cells
    Singapore | Pending
  • selective delivery of material to cells
    Korea (south) | Granted | 10
  • selective delivery of material to cells
    United States of America | Granted | 10,870,112
  • selective delivery of material to cells
    United States of America | Granted | 10,124,336
  • selective delivery of material to cells
    Korea (south) | Granted | 10
  • selective delivery of material to cells
    United States of America | Granted | 11,806,714
  • selective delivery of material to cells
    Belgium | Granted | 3,033,184
  • selective delivery of material to cells
    Switzerland | Granted | 3,033,184
  • selective delivery of material to cells
    Germany | Granted | 3,033,184
  • selective delivery of material to cells
    Spain | Granted | 3,033,184
  • selective delivery of material to cells
    France | Granted | 3,033,184
  • selective delivery of material to cells
    United Kingdom | Granted | 3,033,184
  • selective delivery of material to cells
    Ireland | Granted | 3,033,184
  • selective delivery of material to cells
    Netherlands | Granted | 3,033,184
  • selective delivery of material to cells
    Korea (south) | Granted | 10
  • selective delivery of material to cells
    Korea (south) | Granted | 10
  • selective delivery of material to cells
    Singapore | Pending
  • selective delivery of material to cells
    Liechtenstein | Granted | 3,033,184

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