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Cyclooctynes for Click Chemistry

Technology / Case number: #23210
Ronald Raines / Brian Graham / Jesús Dones / Nile Abularrage / Brian Gold
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Uncharted Frontiers, Sustainable Future, Advanced Materials
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Synthesis of Covalent Protein Dimers that can Inhibit MYC-Driven Transcription

Technology / Case number: #23305WJ
Bradley Pentelute / Isaac Klein / Carly Schissel / Sebastian Pomplun / Andrei Ioan Loas / Jacob Rodriguez / Muhammad Jbara / Ann Boija / Susana Hawken / Charles Li / Stephen Buchwald
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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RNA-Loaded Lipid Nanoparticle (LNP)

Technology, Tangible Property / Case number: #24973H
Byungji Kim / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Target for Modulating Body Mass

Technology / Case number: #21326
Nikola Ivica / Yingzhong Li / Ting Dong / Jianzhu Chen
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Programmable RNA Writing with the Novel RNA-Guided RNA-Targeting CRISPR-Cas7-11 Enzyme

Technology / Case number: #24072
Omar Abudayyeh / Jonathan Gootenberg / Wenyuan Zhou / Cian Schmitt-Ulms / Alisan Kayabolen
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Structure and Engineering of the Type III-E CRISPR-Cas7-11 Effector Complex

Technology / Case number: #23945J
Omar Abudayyeh / Jonathan Gootenberg / Wenyuan Zhou / Hiroshi Nishimasu / Kazuki Kato / Cian Schmitt-Ulms
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Synthetic Cell/Condition-Specific Promoters and Enhancers

Technology / Case number: #18570
Timothy Lu / Lior Nissim / Ming Ru Wu
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Transcriptional Sensor for Bile Acids in Bacteroides Thetaiotaomicron

Technology / Case number: #18573
Christopher Voigt / Mao Taketani
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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DNA Virus Launched RNA Replicon System (VREP) for Prolonged and High Level Expression of Transgenes with High Precision Controls

Technology / Case number: #20866
Ron Weiss / Jacob Becraft / Jin Huh
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Systems, Methods, And Compositions For RNA-Guided RNA-Targeting CRISPR Effectors from Type III Systems

Technology / Case number: #23239
Omar Abudayyeh / Jonathan Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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High-Throughput Untranslated Region Engineering and Screening

Technology / Case number: #19123
Timothy Lu / Manolis Kellis / Jicong Cao / Eva Maria Novoa Pardo / Zhizhuo Zhang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Multilayer Genetic Safety Kill Circuits Based on Single Cas9 Protein and Multiple Engineered gRNA in Mammalian Cells

Technology / Case number: #18163
Ron Weiss / Mohammad Reza Ebrahimkhani / Samira Kiani
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Engineered Yeast As a Method for Bioremediation

Technology / Case number: #18804
George Sun / Angela Belcher
Technology Areas: Biotechnology / Environmental Engineering
Impact Areas: Climate Stabilization, Sustainable Future
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Splicing-Dependent Transcriptional Gene Silencing or Activation

Technology / Case number: #20890
Ana Fiszbein / Christopher Burge
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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RNA Scaffolded Wireframe Origami

Technology / Case number: #24153
Mark Bathe / Tyson Shepherd / Molly Parsons
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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