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Methods for the Treatment of Trinucleotide Repeat Expansion Disorders Associated with FAN1 activity via Targeting of FAN1 Splice Site Inhibitory Sequences

Technology / Case number: #24829
Christopher Ng / David Housman
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Adaptive, Integrated Mycotecture for Food, Composites and Mycoremediation

Technology / Case number: #24500X
Andreas Mershin
Technology Areas: Agriculture & Food / Chemicals & Materials
Impact Areas: Climate Stabilization
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Predictor of Deletions after Targeted Chromosome Cleavage

Technology / Case number: #21045
Max Shen / Jonathan Hsu / David Gifford
Technology Areas: Biotechnology / Computer Science
Impact Areas: Healthy Living, Connected World
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Instructional Materials for Teaching Transfer RNA

Case number: #20436C
John Vandiver
Technology Areas: Biotechnology / Communication Systems
Impact Areas: Connected World
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Using CRISPR/Cas9 to Encode Cellular History

Technology / Case number: #18025R
Alexander Shalek / Alethe Gaillard de Saint Germain
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Formulated, Biodegradable Polymeric Nanoparticles for Nucleic Acid Delivery to Non-Liver Targets

Technology / Case number: #19802
Kevin Kauffman / James Kaczmarek / Asha Patel / Luke Rhym / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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High-Throughput Screens for Exploring Biological Functions of Microscale Biological Systems

Technology / Case number: #19737JR
Paul Blainey / Navpreet Ranu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Lipid Compositions for Delivery of Therapeutic Agents Comprising Cationic Lipids

Technology / Case number: #23842J
Sho Toyonaga / Theresa Raimondo / Dennis Shi / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Novel Ionizable Lipids Suitable For Lipid Nanoparticle Delivery of mRNA to Lung and Nasal Epithelium, As Well As Lung Endothelium

Technology / Case number: #23594Q
Luke Rhym / Allen Jiang / Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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New Ionizable Lipid Library Suitable for Multiple Organ Targeting Derived From High Throughput Combinatorial Synthesis and Screening

Technology / Case number: #23406
Bowen Li / Akiva Gordon / Idris Raji / Daniel Anderson
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Single-Cell RNA Sequencing Using Click-Chemistry

Technology / Case number: #20396
Dig Mahat / Phillip Sharp
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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In-Pipe Leak Detection System

Technology, Tangible Property / Case number: #19034JC
Rached Mansour / You Wu / Kristina Kim / Michael Henry / Kamal Youcef-Toumi
Technology Areas: Agriculture & Food / Environmental Engineering / Sensing & Imaging
Impact Areas: Sustainable Future
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Low-Pressure, Compact Inline Pressure-Compensating Drip Emitter

Technology / Case number: #24489
Amos Winter / Aditya Avinash Ghodgaonkar
Technology Areas: Agriculture & Food
Impact Areas: Sustainable Future
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Controller for Management of Optimal Schedules, used with Renewable-Energy Powered Irrigation Systems

Technology / Case number: #24578
Amos Winter / Georgia Van de Zande / Fiona Grant / Shane Pratt / Carolyn Sheline / Simone Gelmini
Technology Areas: Agriculture & Food / Environmental Engineering / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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Oleogel Drug Delivery Systems for Pediatric Applications

Technology / Case number: #22116J
Carlo Giovanni Traverso / Ameya Kirtane / Robert Langer / Aniket Wahane / Christina Karavasili
Technology Areas: Agriculture & Food / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Biodegradable Polymers for Messenger RNA Delivery to the Lung

Technology / Case number: #19314
Kevin Kauffman / James Kaczmarek / Asha Patel / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Structure-Guided Chemical Modification of Guide RNA and its Applications

Technology / Case number: #19175V
Hao Yin / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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sgRNA Chemical Modification for Efficient Gene Editing

Technology / Case number: #17805V
Hao Yin / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Single Administration, Multi-Dose, Multi-Therapeutic Capable Delivery Platform for Veterinary Applications

Technology / Case number: #20943J
Carlo Giovanni Traverso / Alex Abramson / Ester Caffarel Salvador / Robert Langer / Christoph Winfried Johannes Steiger / Michael Williams / Jacob Coffey / Jason Li / Miguel Jimenez / Tiffany Hua
Technology Areas: Agriculture & Food / Biotechnology
Impact Areas: Healthy Living, Advanced Materials
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Cationic Lipidoids and Their Uses for Immunotherapy

Technology / Case number: #19803
Linxian Li / Yuxuan Huang / Lei Miao / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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