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Systems, Methods, And Compositions For RNA-Guided RNA-Targeting CRISPR Effectors from Type III Systems

Technology / Case number: #23239
Omar Abudayyeh / Jonathan Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Chemoselective Modification of mRNA Using Palladium Oxidative Addition Complexes

Technology / Case number: #25265
Bradley Pentelute / Andrei Ioan Loas / Jacob Rodriguez / Stephen Buchwald
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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Protein Corona Phase Molecular Recognition (CoPhMoRe)

Technology / Case number: #18316
Michael Strano / Gili Bisker Raviv
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living
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Engineered Phagemids for Non-Lytic, Targeted Antibacterial Technologies

Technology / Case number: #18186HJY
James Collins / Russell-John Krom / Prerna Bhargava / Michael Lobritz
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Electromechanical Lysis of Bacterial Pathogens using Ion Concentration Polarization

Technology / Case number: #19035
Minseok Kim / Jongyoon Han
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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PNA Amphiphile Adjuvant Delivery Vehicles

Technology / Case number: #18878H
Eric Dane / Darrell Irvine
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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M13 Phage Assembly System for Optimal Blood Trafficking, Tumor Penetration, and Passage Across the Blood Brain Barrier

Technology / Case number: #19438
Uyanga Tsedev / Fred Lam / Angela Belcher
Technology Areas: Drug Delivery / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Compositions and Methods for Treating and Preventing Obesity

Technology / Case number: #18085J
Manolis Kellis / Melina Claussnitzer / Jan Korbel
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Open-Ended, Dicer-Cleavable Concatemeric siRNA Generated by Rolling Circle Transcription

Technology / Case number: #18076
Connie Wu / Kevin Shopsowitz / Paula Hammond
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Delivery of Preassembled Double-Stranded Short Interference RNA-Argonaute Protein Complexes for Enhanced RNAi-Based Therapeutics

Technology / Case number: #19340
Jiahe Li / Yanpu He / Wade Wang / Paula Hammond
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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Manufacture of Thermo-Responsive Hydrogel Composing of Drug-Nanocapsule for Sustainable Release of Ibuprofen, Ofloxacin and Dexamethasone

Technology / Case number: #18561
Jeremiah Johnson / Qixian Chen / Farrukh Vohidov
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Structured DNA Conjugates

Technology / Case number: #18588
Mark Bathe / Sakul Ratanalert / Remi Veneziano / Tyson Shepherd / Hyungmin Jun
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Layer-by-Layer Nanoparticles for Cytokine Therapy in Cancer Treatment

Technology / Case number: #20027H
Erik Dreaden / Mariane Melo / Antonio Barberio / Santiago Correa Echavarria / Talar Tokatlian / Darrell Irvine / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Dendrimer Drug Conjugates for Sustained Intra-Articular Delivery

Technology / Case number: #19214
Brett Geiger / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Highly Parallel Enzymatic DNA Synthesis Using Electrowetting Droplet Technology

Technology / Case number: #19620
Mark Bathe / Tyson Shepherd / James Banal / Joseph Berleant
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Methods for Gene Delivery with Papillomaviruses

Technology / Case number: #21704
Omar Abudayyeh / Jonathan Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Removal of Ruthenium-Initiator from Brush-Arm Star Polymers (BASPs) via Core-to-Surface Ring-Opening Methathesis Polymerization (ROMP)

Technology / Case number: #19525
Jeremiah Johnson / Matthew Golder
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Set of Educational Building Blocks to Model the Process of Assembly of Proteins from Amino Acids

Technology / Case number: #18361
Kathleen Vandiver / John Vandiver
Technology Areas: Biotechnology
Impact Areas: Connected World
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RNA-Based Regulatory Technologies for Improved miRNA Sensors

Technology / Case number: #19686
Ron Weiss / Kevin Lebo / Jin Huh
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Manuka Honey Microneedle: Methods and Uses

Technology / Case number: #21539
Galit Frydman / David Olaleye / Illina Yang / Damodaran Annamalai
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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