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Methods for the Treatment of Trinucleotide Repeat Expansion Disorders Associated with FAN1 activity via Targeting of FAN1 Splice Site Inhibitory Sequences

Technology / Case number: #24829
Christopher Ng / David Housman
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Closed-Loop Noninvasive Brain Stimulation with Simultaneous Imaging to Control Cerebrospinal Fluid Flow in Humans

Technology / Case number: #25482
Laura Lewis / Joshua Levitt
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Computer Science / Sensing & Imaging
Impact Areas: Healthy Living
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Ingestible Electronics Integrated with Flexible Measurement Electrodes for Gastrointestinal Bioelectric Sensing

Technology / Case number: #23241
Carlo Giovanni Traverso / Robert Langer / Siheng You / So-Yoon Yang / Adam Gierlach / George Selsing
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Computer Science
Impact Areas: Healthy Living, Advanced Materials
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A Natural Language Diet Tracking Smartphone Application

Software / Case number: #19264
Mandy Korpusik / James Glass
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biomaterials & Bioelectronics / Communication Systems
Impact Areas: Healthy Living, Connected World
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Predictor of Deletions after Targeted Chromosome Cleavage

Technology / Case number: #21045
Max Shen / Jonathan Hsu / David Gifford
Technology Areas: Biotechnology / Computer Science
Impact Areas: Healthy Living, Connected World
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Machine Learning Model for Diagnosis of Various Pulmonary Diseases -- Logistic Regression

Software / Case number: #22332
Daniel Chamberlain / Christian Infante / Richard Fletcher
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biomaterials & Bioelectronics / Computer Science
Impact Areas: Healthy Living, Advanced Materials
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Machine Learning Model for Diagnosis of Various Pulmonary Diseases -- Bayesian

Software / Case number: #22333
Aneesh Anand / Richard Fletcher
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biomaterials & Bioelectronics / Computer Science
Impact Areas: Healthy Living
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Signal Processing and Machine Learning Algorithm for Assessing Atherosclerosis and Coronary Arterial Disease from Multi-Site PPG Data

Software / Case number: #22643
Niccolo Pignatelli / Botong Ma / Victoria Ouyang / Richard Fletcher
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biomaterials & Bioelectronics / Computer Science
Impact Areas: Healthy Living, Uncharted Frontiers
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PPG Pulse Analysis and Signal Processing for Determination of Cardiovascular Risk

Software / Case number: #22644
Niccolo Pignatelli / Victoria Ouyang / Richard Fletcher
Technology Areas: Biomaterials & Bioelectronics / Computer Science
Impact Areas: Healthy Living
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Instructional Materials for Teaching Transfer RNA

Case number: #20436C
John Vandiver
Technology Areas: Biotechnology / Communication Systems
Impact Areas: Connected World
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Using CRISPR/Cas9 to Encode Cellular History

Technology / Case number: #18025R
Alexander Shalek / Alethe Gaillard de Saint Germain
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Formulated, Biodegradable Polymeric Nanoparticles for Nucleic Acid Delivery to Non-Liver Targets

Technology / Case number: #19802
Kevin Kauffman / James Kaczmarek / Asha Patel / Luke Rhym / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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High-Throughput Screens for Exploring Biological Functions of Microscale Biological Systems

Technology / Case number: #19737JR
Paul Blainey / Navpreet Ranu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Lipid Compositions for Delivery of Therapeutic Agents Comprising Cationic Lipids

Technology / Case number: #23842J
Sho Toyonaga / Theresa Raimondo / Dennis Shi / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Novel Ionizable Lipids Suitable For Lipid Nanoparticle Delivery of mRNA to Lung and Nasal Epithelium, As Well As Lung Endothelium

Technology / Case number: #23594Q
Luke Rhym / Allen Jiang / Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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New Ionizable Lipid Library Suitable for Multiple Organ Targeting Derived From High Throughput Combinatorial Synthesis and Screening

Technology / Case number: #23406
Bowen Li / Akiva Gordon / Idris Raji / Daniel Anderson
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Single-Cell RNA Sequencing Using Click-Chemistry

Technology / Case number: #20396
Dig Mahat / Phillip Sharp
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Quick Release Capsules for Small Intestine Delivery

Technology / Case number: #20105J
Carlo Giovanni Traverso / Daniel Minahan / Alex Abramson / Niclas Roxhed / Ester Caffarel Salvador / David Dellal / Vance Soares / Robert Langer / Christoph Winfried Johannes Steiger / Morten Frederiksen
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Engineering a Swine Macro-Organ Colorectal Cancer Platform to Combat Transport-Induced Chemotherapy Resistance

Technology / Case number: #22864JQ
Carlo Giovanni Traverso / Yunhua Shi / Vance Soares / Daniel Reker / Robert Langer
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
License

Closed-Loop Ingestible Robot for Radiation and Chemical Sensing

Technology / Case number: #22735
Carlo Giovanni Traverso / Hen Wei Huang / James Byrne
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Industrial Engineering & Automation / Sensing & Imaging
Impact Areas: Healthy Living, Uncharted Frontiers
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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