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In Solution Monoclonal Polony Generation on Inorganic Nanoparticle

Technology / Case number: #25039
Ashwin Gopinath / Nayan Agarwal / Emily Wu
Technology Areas: Chemicals & Materials / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Advanced Materials
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A Multi-Pathway Reporter System that Interrogates Repair of DNA Double-Strand Breaks with Applications for Diagnosis and Therapeutic Treatment of Cancer and Neurodegenerative Diseases

Technology / Case number: #25444
Alex Kruswick / Michael Yaffe
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Multiplexed in Vivo Disease Sensing with Nucleic Acid-Barcoded Reporters enabling CRISPR-Cas-based Detection

Technology / Case number: #21723H
Liangliang Hao / Renee Zhao / Chayanon Ngambenjawong / Sangeeta Bhatia
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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Intra-Tumoral Injection of Cytotoxic Chemotherapy-Treated Tumor Cells in Combination with Systemic Immune Checkpoint Blockade for Cancer Treatment

Technology / Case number: #21498H
Ganapathy Sriram / Lauren Milling / Darrell Irvine / Michael Yaffe
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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TRAV-007 (Genome Sequencing) 62/790,799

Technology / Case number: #22143J
Robert Kimmerling / Mark Stevens / Keith Ligon / Scott Manalis
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Activity-based Cell Sorting

Technology / Case number: #23765HJ
Jesse Kirkpatrick / Ava Soleimany / Sangeeta Bhatia
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Autocatalytic Base Editing for RNA-Responsive Translational Control

Technology / Case number: #24552YJ
James Collins / Raphael Gayet / Katherine Ilia / Shiva Razavi / Nathaniel Tippens / Kehan Zhang / Xiaoyu Chen / Jonathan Chen / Makoto Lalwani
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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TRAV-005 (Needles) 62/795,857

Technology / Case number: #22144J
Selim Olcum / Robert Kimmerling / David Weinstock / Scott Manalis
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Modified Viscoelastic Assay Rapidly Unmasks Pathological Fibrinolysis Phenotypes in a Wide Spectrum of Human Diseases

Technology / Case number: #19496J
Christopher Barrett / Ernest Moore / Hunter Moore / Michael Yaffe
Technology Areas: Biotechnology / Diagnostics
Impact Areas: Healthy Living
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Rapid Droplet-Based Systems for Antibody Drug Discovery

Technology / Case number: #23890J
Brandon DeKosky / Matias Gutierrez Gonzalez / Cheng-yu Chung / Ahmed Fahad / Nicoleen Boyle / Shuyan Jin
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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High-throughput Electroporation Device

Technology / Case number: #21871
Cullen Buie / Po-Hsun Huang / Sijie Chen
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Targeting Lung Microbiota and its Responding Immune Pathways for Lung Cancer Treatment

Technology / Case number: #20602HRJ
Paul Blainey / Chengcheng Jin / Georgia Lagoudas / Tyler Jacks
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Programmable RNA Writing with the Novel RNA-Guided RNA-Targeting CRISPR-Cas7-11 Enzyme

Technology / Case number: #24072
Omar Abudayyeh / Jonathan Gootenberg / Wenyuan Zhou / Cian Schmitt-Ulms / Alisan Kayabolen
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Structure and Engineering of the Type III-E CRISPR-Cas7-11 Effector Complex

Technology / Case number: #23945J
Omar Abudayyeh / Jonathan Gootenberg / Wenyuan Zhou / Hiroshi Nishimasu / Kazuki Kato / Cian Schmitt-Ulms
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Transcriptional Sensor for Bile Acids in Bacteroides Thetaiotaomicron

Technology / Case number: #18573
Christopher Voigt / Mao Taketani
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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An RNA Sequencing Method for Absolute Quantification of RNA Molecules

Technology / Case number: #20363
Peter Dedon / Michael DeMott / Bo Cao / Jennifer Hu
Technology Areas: Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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rcSso7d.SA Oligomer-PNIPAM Conjugates

Technology / Case number: #20442
Bradley Olsen / Hadley Sikes / Eric Miller / Justin Paloni
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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High-Throughput Native Context Mapping of the Regulatory Genome

Technology / Case number: #18012JQ
Nisha Rajagopal / Richard Sherwood / David Gifford
Technology Areas: Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Method to Distinguish and Analyze White Blood Cells in the Presence of Red Blood Cells

Technology / Case number: #18889
Shivang Dave / Jason Tucker-Schwartz
Technology Areas: Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Compounds, Targets and Pathways for Macrophage Modulation

Technology / Case number: #22081
Guangan Hu / Jianzhu Chen
Technology Areas: Diagnostics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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