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Methods for the Treatment of Trinucleotide Repeat Expansion Disorders Associated with FAN1 activity via Targeting of FAN1 Splice Site Inhibitory Sequences

Technology / Case number: #24829
Christopher Ng / David Housman
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Methods for Improving Cross-Ancestry Transferability in Predicting Polygenic Phenotypes from Genetic Variation

Technology / Case number: #24858
Manolis Kellis / Yosuke Tanigawa
Technology Areas: Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Bioelectronic Devices to Support Transplanted Cells in Vivo for Encapsulated Cell Therapies

Technology / Case number: #23269J
Suman Bose / Robert Langer / Siddharth Krishnan / Matthew Bochenek / Nima Khatib / Daniel Anderson
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Energy & Distribution / Therapeutics
Impact Areas: Healthy Living
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Multisensory Gamma Stimulation Promotes Glymphatic Clearance of Amyloid

Technology / Case number: #25696PH
Li-Huei Tsai / Edward Boyden / Ping-Chieh Pao / Cheng-Yi Yang / Mitchell Murdock
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Composite Anti-Fouling Coatings Designed via Full Spectral Hamaker Constant Minimization

Technology / Case number: #21606J
Michael Short / Max Carlson / Robert Simpson
Technology Areas: Chemicals & Materials / Energy & Distribution / Environmental Engineering
Impact Areas: Climate Stabilization, Sustainable Future
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Gas Injection System for Plasma Blackout Alleviation Studies

Technology / Case number: #23238
Wesley Harris / Humberto Caldelas
Technology Areas: Energy & Distribution / Industrial Engineering & Automation
Impact Areas: Sustainable Future, Connected World
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Super-MIEC Anodes for High-Rate Lithium-Ion Batteries

Technology / Case number: #23400
Ju Li / Shitong Wang / Yanhao Dong
Technology Areas: Energy & Distribution
Impact Areas: Sustainable Future, Advanced Materials
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Wide-Range Switched-Mode Power Amplifier Architecture

Technology / Case number: #24814
Khandoker N Rafa Islam / Xin Zan / David Perreault
Technology Areas: Energy & Distribution
Impact Areas: Sustainable Future, Advanced Materials
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Liquid Sandwich Vacuum Vessel for Magnetic Fusion

Technology / Case number: #22157
Sara Ferry / Dennis Whyte / Caroline Sorensen / Ethan Peterson / Jeffrey Freidberg
Technology Areas: Energy & Distribution
Impact Areas: Sustainable Future, Advanced Materials
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Cryogenic Integrated Circuits Architecture for Multiplexed Chemical-Shift NMR

Technology / Case number: #22378
Dirk Englund
Technology Areas: Chemicals & Materials / Computer Science / Electronics & Photonics / Energy & Distribution
Impact Areas: Connected World, Advanced Materials
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Radiatively Recuperated Reactor System for Temperature-Swing Chemical Looping Fuel-Production Processes

Technology / Case number: #22359
Ahmed Ghoniem / Aniket Patankar / Xiaoyu Wu / Won Jae Choi / Harry Tuller
Technology Areas: Energy & Distribution
Impact Areas: Sustainable Future
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CHF Enhancing Surface Treatment

Technology / Case number: #21378
Evelyn Wang / Matteo Bucci / Olorunsola Akinsulire / Bren Phillips / Youngsup Song / Chi Wang / Guanyu Su / Md Mahamudur Rahman
Technology Areas: Chemicals & Materials / Electronics & Photonics / Energy & Distribution
Impact Areas: Sustainable Future, Advanced Materials
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Using CRISPR/Cas9 to Encode Cellular History

Technology / Case number: #18025R
Alexander Shalek / Alethe Gaillard de Saint Germain
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Genotype-Directed Local Delivery of Targeted Therapeutics at the Tumor Margin

Technology / Case number: #19863J
Carlo Giovanni Traverso / Ameya Kirtane / Daniel Cahill / Ganesh Shankar / Robert Langer
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Formulated, Biodegradable Polymeric Nanoparticles for Nucleic Acid Delivery to Non-Liver Targets

Technology / Case number: #19802
Kevin Kauffman / James Kaczmarek / Asha Patel / Luke Rhym / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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High-Throughput Screens for Exploring Biological Functions of Microscale Biological Systems

Technology / Case number: #19737JR
Paul Blainey / Navpreet Ranu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Using over Wnt ing to Treat Colon Cancer: Small Molecule GSK3 Inhibitors and Novel Protein Isolation

Technology / Case number: #23378J
George Eng / Omer Yilmaz / Jonathan Braverman
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Single-Cell RNA Sequencing Using Click-Chemistry

Technology / Case number: #20396
Dig Mahat / Phillip Sharp
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Diagnosis of Malignancy Using Developmental Relationships and Machine Learning

Technology / Case number: #23356
Salil Garg / Enrico Moiso
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Bioinspired Design of Self-Adjuvanted C3d-Fusion SARS-CoV-2 mRNA Vaccines

Technology / Case number: #23326
Robert Langer / Bowen Li / Allen Jiang / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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