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Advantages

  • A wide array of gene editing material encapsulated in the HPV derived capsid vector can be used. 

  • HPV delivery system can elude the host immune system, therefore increasing the range of tissues and cell types that can be targeted (i.e., astrocytes, hematopoietic stem cells, esenchymal progenitor cell, muscle cell, retinal cell). 

  • Allows In vivo cellular engineering for constructs up to 8 kb. 

  • HPV capsids can be modified to enhance transduction efficiency.