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Advantages

 

  • The RADARs can function with either endogenous cellular ADAR or exogenous ADAR.  
  • Ability to control expression of synthetic mRNA, an important feature for mRNA therapeutics and vaccines. 

  • Detection sensitivity on endogenous transcripts as low as 13 transcripts per million (TPM). 

  • This technology can be expressed via DNA or synthetic mRNA. 

  • A wide variety of payloads can be attached to the sensor system, which the inventors have demonstrated for luciferase, fluorescent proteins, and caspases.