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Problem Addressed

Due to advances in single-cell technologies, there are a large number of cell types and states that can now be measured and defined by expressed RNA. However, there is still a lack of strictly observational sensor systems to track and measure RNA levels in vivo. Additionally, techniques that integrate sensors to track RNA levels require the use of transgenic organisms, which are often not feasible in many scenarios due to their imprecision and inflexibility. A strictly observational RNA sensor would enable cell-state specific tracking and perturbation with high sensitivity, thereby overcoming the unforeseen consequences on gene expression inherent with current methods.