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This technology is a collection of methods that can be used to identify modulators of macrophages for disease intervention. Macrophages are a key class of phagocytic cells, which engulf and degrade dying cells and invading bacteria and viruses. The dysregulation of macrophages has been implicated in contributing to numerous human diseases. By identifying modulators that activate macrophages, these macrophages can be “re-programmed” to treat such diseases.