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Problem Addressed

Split protein reporter systems have potential applications for research of cell signaling events, detection of interactions between different cell types, sensing of environment pollutants, quantification of biomarkers, and diagnosis of disease states, including allergies and infectious diseases. Most existing split protein reporter systems are limited in that they enable detection by only a single modality (i.e. fluorescent or colorimetric or chemiluminescent). Furthermore, many split protein reporters are limited in their sensitivity of detection, with each detection event generating only a weak luminescent signal.