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Problem Addressed

The use of magnetic fields for the minimally invasive control of cell signaling molecules, such as calcium, is gaining recognition as an approach to studying the nervous system and mechanosensitive cell biology. In fact, wireless strategies using high-frequency alternating magnetic fields to heat magnetic nanoparticles have already been demonstrated to permit the regulation of neural activity in vivo. However, the off-target effects of magnetothermal approaches, including cellular damage, and the challenges in scaling high-frequency alternating magnetic field apparatuses are obstacles to the widespread adoption of these strategies in biomedical applications. Therefore, there is a need for scalable magnetic devices that can be used in conjunction with lower-frequency magnetic fields to control and study cellular activity and signaling without compromising cellular viability. The present invention is a novel method and device that provides remote magnetomechanical control of mechanosensitive cells to regulate calcium flux utilizing low-frequency magnetic fields and magnetic nanodiscs.