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Problem Addressed

The circuit-based neurological disorders are due to a failure in communication between multiple brain areas as opposed to a deficit in a single brain area.  Hence, the treatment of circuit-based disorders is far more effective when targeted to normalize neural activity across a circuit instead of focusing treatment on a single neural tissue.  The brain uses both chemical and electrical methods of communication; therefore, combining chemically- and electrically-based therapeutic approaches has great potential for normalizing neural activity across brain circuits.  However, systemic administration of drugs frequently leads to drug tolerance and dose escalation.  Moreover, currently available micro-cannula devices have limited functions and are not scalable to larger animal models or to clinical applications.  Hence, a single device that is capable of delivering drugs while performing simultaneous electrical stimulation is needed to precisely tune neural activity.