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  • DNA stimuli-responsive hydrogel that leverages the specificity and programmability of the CRISPR-Cas system
  • Target specificity is easily modulated through simple replacement of the guide RNA sequence
  • Low concentrations of DNA stimulus are required to induce response
  • Demonstrated uses for this versatile technology include controlled release of bound payloads (e.g., fluorescent molecules, active enzymes, nanoparticles, or live cells), degradable electrical fuses, and valves in fluidic devices
  • Wide range of applications in medicine, tissue engineering, bioelectronics, and environmental monitoring