This invention introduces a beveled tip to the distal end portion of microcapillary medical probe used for insertion into soft tissues, such as the brain. The probe may include devices for drug delivery, fluid withdrawal, or electrical stimulation/monitoring. The geometry of the beveled tip is critical to producing the asymmetric force and deflection required for non-linear steering of the probe into the target tissue; the angle of the beveled tip correlates to the radius of curvature of the insertion path. The relationship between beveled tip angle design and trajectory allows for anatomical targeting that is highly predictable and reproducible.
This probe can be guided without real-time imaging guidance or the use of a larger shuttle to accurately reach the target site in the tissue. Rotational steering of the beveled tip can be utilized to avoid more sensitive anatomical structures, and for reaching two or more different target sites without withdrawing and reinserting the probe to minimize collateral tissue damage. The capability of beveled tip microcapillaries to follow reliable trajectories has been demonstrated by the inventors in agarose gel tissue models as well as ex vivo swine brains, indicating strong potential for translation to the clinical setting in the brain and other solid organs.