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Technology

This invention generates artificially engineered respiratory mucin mimetic proteins that can be post-translationally modified through diazonium coupling to generate glycosylated products. The mucin mimetic proteins can then be extended via the oxidative coupling of cysteine residues to produce high molecular weight, densely functionalized mucin mimetic materials. The engineered mucin mimetic is comprised of the most frequent sequence of the variable number tandem repeats (VNTR) of respiratory mucins. Serines and threonines in these repeats have been replaced with tyrosines to facilitate diazonium-coupling and functionalization of the protein. Flanking the VNTR with cysteine residues facilitates protein-chain elongation through disulfide coupling.