Header and Body 2

Problem Addressed

Mucins are highly glycosylated, high molecular weight polymers that are very challenging to synthesize via chemical or molecular biology methods. Scraping pig stomachs yields microgram quantities of mucin and is the most common means of obtaining these polymers. However, synthetic methods exists to produce mucins, and are limited by their failure to generate highly glycosylated mucins that retain the physical and functional characteristics of native sources. This invention generates a protein series that mimics native respiratory mucins, generating high molecular weight and densely functionalizable mucin mimetic materials suitable for testing drug bioavailability.