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Problem Addressed

Lung cancer is the leading cause of cancer related deaths worldwide. In non-small cell lung cancer (NSCLC), the largest subtype of lung cancer, 30% of patients have mutation of the KEAP1/NRF2 oxidative stress pathway. Patients with mutation of the KEAP1/NRF2 pathway have highly aggressive tumors with poor prognoses. This technology is a novel way to treat patients with dysregulation of the KEAP1/NRF2 pathway.