Header and Body 3


This technology uses PARP inhibition to boost the efficacy of RNAi targeting. These inventors discovered that PARP12/13 expression prevents effective RNAi-mediated degradation of the target mRNA and that blocking PARP12/13 expression leads to re-activation of the RNAi degradation pathway, thereby boosting mRNA degradation. These findings indicate that PARP suppression has the potential to boost RNAi responses, and suggests that PARP inhibition could be used in combination with RNAi therapeutics to increase cellular responses.