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Problem Addressed

An estimated 90% of cancer deaths are due to tumor metastasis, which is the dissemination of tumor cells from the primary tumor site to distant organs and tissues. Despite the fact that metastasis is the primary driver of cancer mortality, there has been very little drug development targeting metastasis inhibition, and there is only one FDA approved anti-metastasis drug on the market today. There is therefore a significant unmet need to develop drugs that block metastatic dissemination of cancer cells.