Electrical cell permeation is currently the preferred lysis technique. It is a simple process without lytic additives, enabling prompt lysis of cells. However, electrical cell permeation requires high voltage electric fields that often result in intracellular biomolecule degradation, bacterial sample overheating, and undesirable bubble generation. Non-optimal low voltage levels and low-salinity solutions must be used to compensate for these impediments. This produces incomplete lysis and lower throughput. This electromechanical lysis invention enables the rapid, continuous, versatile, and high-throughput lysis of various bacterial pathogens by applying a very low voltage.