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This technology universally stabilizes proteins to prevent aggregation using polyamidoamine (PAMAM) dendrimers with a guanidinium surface. The PAMAM dendrimers are an order of magnitude more efficient at preventing protein aggregation than other commonly used excipients such as sucrose and arginine hydrochloride. Aggregation rate is one of the primary determinants of the shelf life of protein therapeutics, and the use of PAMAM dendrimers extends the shelf life proteins formulations to nearly 5 months at room temperature compared to under 2 weeks for traditional excipients. In addition to use as an excipient, PAMAM dendrimers can be used to prevent aggregation in the high temperature reaction conditions needed to make recombinant proteins, thereby increasing yield and preventing aggregates from clogging machinery.