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Problem Addressed

Recombinant synthesis techniques are used throughout molecular biology to make proteins for research and therapeutic purposes. To make a protein, DNA is first transcribed into an RNA intermediate, then the RNA is translated into protein. There have been many improvements in boosting the efficiency of the first transcription step of protein expression, but there has thus far been little innovation in boosting translation efficiency from RNA into protein. These inventors developed a novel technique for boosting protein expression in human cells by increasing RNA to protein translation.