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Problem Addressed

Zinc is an essential nutrient. Chelatable or “mobile” forms of zinc can act as signaling agents, the actions of which have been directly implicated in numerous physiological and pathological processes, such as neurotransmission, neurogenesis, cancer, diabetes, and acute inflammation.  Understanding the role of mobile zinc in biology requires tools that can be used to visualize and track the changes of mobile zinc levels in diverse cellular and subcellular environments. Unfortunately, most commercially available small-molecule probes for mobile zinc have a narrow dynamic range, adventitious localization, and/or a pH-sensitivity, which limits their utility.