Header and Body 3


The core of this technology relies on the discovery that autoimmune CD4+ T response to heat shock proteins 27 (hsp27) and or (hsp60) in the pathogenesis of glaucoma. The autoimmune response initiated by elevated intraocular pressure (TOP) is a key component in causing progressive retinal ganglion cell (RGC) and axonal degeneration in glaucoma.

This invention provides a method for the early diagnosis and evaluation of treatment efficacy, associated to heat shock proteins (hsp27 or hsp60) by detecting auto-antigen-reactive T cells or auto-antigen-antibodies. The invention also provides a therapeutic treatment of glaucoma, anterior ischemic optic neuropathy (AION), and optic nerve trauma by inhibiting an autoimmune response triggered by elevated TOP, ischemia, trauma or other injuries in a subject.