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Problem Addressed

Biologic pharmaceuticals have revolutionized the drug industry, and biologics are currently one of the fastest growing areas of therapeutic development. One of the current struggles in biologic manufacturing is achieving high per-cell productivity to maximize protein titer. Methylotrophic yeast, such as Pichia, have recently gained popularity due to their rapid growth and post-translational modification capabilities. However, the expression vectors available for protein production in methylotrophic yeast lag far behind those for other cell systems, and there is a need for optimized vector systems to increase protein expression.