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MiNDS is a micro-fabricated, minimally invasive, implantable, remotely controllable drug delivery device. It utilizes pumps under wireless control to deliver nanoliters of drugs. This permits the adjustment of therapeutic regimens with pin point accuracy. MiNDS has a minimally invasive, yet robust, stainless steel Hamilton needle capable of penetrating deep brain structures without mechanical failure for chronic implantation. It is 200 μm in diameter, preventing significant tissue damage; and it has an aspect ratio of 500 (depth to diameter) limiting off-target drug diffusion. MiNDS also utilizes a tungsten electrode to record neuronal activity at the single-cell and population level to help analyze the effects of delivered drugs.