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Problem Addressed

Many current physical drug delivery technologies to the brain utilize catheters which commonly deliver drugs to the ventricular system. However, penetrance with these technologies tends to be uneven and severely compromised by the distance between the target site and the ventricular system. Probes are another physical drug delivery technique; however, they pose their own set of challenges such as off-target diffusion. Large dimension probes can reach deep brain structures, but they cause significant gliosis and related deleterious tissue reactions. Smaller probes have mainly been applied intracortically, penetrating only into superficial regions of the brain due to a low bending stiffness. There is a need for a robust drug delivery mechanism, such as MiNDS, that is capable of accessing deep brain structures without causing significant tissue damage or off-target drug distribution.