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Problem Addressed

Chronic pain is a debilitating condition that is associated with significant medical, emotional, and economic burdens for which few effective treatments are available. Current chronic pain therapies, such as opioids are mostly ineffective or have major off- target effects, such as addictiveness due to action on other neuronal subtypes. In the brain, nociceptor sensory neurons mediate the detection of harmful/injurious stimuli, and their activation produces chronic pain. Nociceptor neurons are dysregulated in muscle spasticity, which may contribute to overactive sensori-motor reflexes, and also innervate joints affected in osteoarticular conditions in order to mediate pain.