MEECs contain healthy endothelial cells in a three-dimensional biocompatible substrate, such as a collagen-based scaffold. After liver resection, the MEECs are implanted in direct contact with the remaining liver tissue. The endothelial cells within the MEECs and the cells of the liver physiologically communicate and cooperate during hepatic repair. This aids the liver in recovering endothelium functionality; therefore, the liver can regenerate tissue and hepatocyte function more effectively by creating a functional vascular splice. In addition, the healthy MEECs switch the proinflammatory profile of Th1 and M1 cells to proregenerative Th2 and M2. This leads to significantly less post-operation reaction and rejection.