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Problem Addressed

The peritoneal cavity is the fluid filled space that surrounds the stomach, intestines, liver, and in women, ovaries. Cancers such as ovarian, colorectal, pancreatic, breast, and cervical cancers can metastasize and form tumors in the intraperitoneal (IP) space. IP metastases have poor prognosis, which is partially due to the lack of effective treatment strategies for IP tumors. Systemic intravenous treatment does not effectively deliver therapeutics to the peritoneum. Delivering drugs directly to the IP cavity can slightly increase efficacy, but most cancer therapeutics are designed for IV delivery and have suboptimal performance when delivered IP. There is therefore a great need for IP optimized drug delivery methods.