Zika virus infections correlate with microcephaly and other serious neurological disorders. Accurate rapid diagnostics are critically needed to monitor patients, especially during pregnancy and to provide epidemiological surveillance. Zika and Dengue viruses co-circulate and share protein homologies, creating the potential for crossover detection problems, and complicating the development of specific diagnostics. There are currently no Zika virus antigen rapid tests. Existing Zika infection diagnosis methods involve Real Time RT-PCR which are time consuming and not widely available. Accurate, available, and inexpensive Zika rapid diagnostics are especially critical for pregnant women or women considering pregnancy.