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Advantages

  • Metal-free T2 negative-contrast agent for MRI imaging of tumors
  • Tumor homing BASP-ORCA particles allow specific tumor contrast enhancement
  • Increases in vivo half-life of nitroxide by protecting from rapid reduction reaction
  • High relaxivity and effective contrast enhancement through incorporation of many nitroxide groups into each BASP-ORCA nanoparticle
  • Multimodal imaging through addition of IR fluorescence functional groups