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This invention uses PNA oligomer as a carrier of CDN, where they form reversible noncovalent complexes through pi-pi base stacking and hydrogen-bond interactions. The PNA oligomer is covalently conjugated to an amphiphile such as diacyl lipid tail, and optionally may include a polyethylene glycol (PEG) molecule. The arrangement of the lipid tail and PEG molecule allows for modulation of size and structure of the synthetic nanoparticle to control CDN delivery based on the desired response.