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Scavenger receptor class B type I (SR-BI)-ΔCT mice in combination with apoE KO or LDLR KO or HypoE allele can be used as a fertile model of rapid onset and fatal occlusive coronary arterial atherosclerosis and coronary heart disease (CHD) in place of combinations with SR-BI KO mice. In addition, the SR-BI-ΔCT mouse alone or in combination can also be used as a mouse model for hypercholesterolemia, macrocytic anemia, hepatic and splenic extramedullary hematopoiesis, massive splenomegaly, reticulocytosis, thrombocytopenia, vascular disease, stroke, arterial thrombosis, deep vein (veinous) thrombosis, Addison’s disease, infectious diseases, and atherothrombosis.