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Problem Addressed

Human embryonic stem cells (hES) and human induced pluripotent stem cells (hiPSCs) have opened up the field of developmental biology and regenerative medicine with access to in vitro model system for understanding development and differentiation, and developing organoids of different cell types. However, most of the technologies so far have focused on generating homogeneous population of specialized cells from a single germ layer, or mixing cells to generate a mimic of complex tissue. This technology utilizes genetic engineering to induce cells of all germ layers that co-develop to form heterogeneous tissue similar to the embryogenesis process.