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Problem Addressed

Molecular recording technologies allow for conversion of transient biological signals into permanent records that can be retrieved later for analysis. Current technologies are capable of recording binary on or off biological signals but are unable to capture analog signals such as duration and/or magnitude of the signal. The current technology employs targeted DNA mutagenesis using CRISPR system to boost the mutation rate without compromising cell viability, and allows for accumulation of mutations to capture information on the strength of the signal.