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Problem Addressed

Many proprietary lentivirus transfer vectors that confer the expression of micro-RNA (miRNA) for gene knockdown via RNA interference (RNAi) either are not inducible, inducible but not expressed in a cell-type-specific manner, or only inducible and cell-type specific with both the additional expression of Cre recombinase and the administration of doxycycline or tetracycline. A more elegant method to create transgenic lines with cell-type-specific knockdown would improve upon current methods.